Tricyclic antidepressant overdose: a review
نویسندگان
چکیده
منابع مشابه
Tricyclic antidepressant overdose: a review.
Overdoses of tricyclic antidepressants are among the commonest causes of drug poisoning seen in accident and emergency departments. This review discusses the pharmacokinetics, clinical presentation and treatment of tricyclic overdose.
متن کاملRisk assessment of severe tricyclic antidepressant overdose.
Prognostic factors for severe complications in tricyclic antidepressant (TCA) overdose remain unclear. We therefore evaluated the value of clinical characteristics and electrocardiograph (ECG) parameters to predict serious events (seizures, arrhythmia, death) in severe TCA overdose of 100 patients using logistic regression models for risk assessment. The overall fatality rate was 6%, arrhythmia...
متن کاملTricyclic antidepressant overdose necessitating ICU admission.
Tricyclic antidepressant (TCA) overdose necessitating intensive care unit (ICU) admission remains a significant problem in the Western Cape. In this retrospective study, we reviewed the course of life-threatening TCA overdose in our centre to identify potential prognostic indicators. TCA levels >1000 ng/ml were associated with QT and QRS prolongation and convulsions. However, no single paramete...
متن کاملCriteria for admitting patients with tricyclic antidepressant overdose.
Several investigators have recently developed guidelines for determining which patients with tricyclic antidepressant overdose should be hospitalized. The width of the QRS complex on the ECG and several clinical parameters have been proposed to identify patients at risk for major complications. To validate these, we developed an algorithm and then applied it to 45 patients who had overdosed on ...
متن کاملIncidence of tricyclic antidepressant-like complications after cyclobenzaprine overdose.
BACKGROUND The cyclobenzaprine structure is similar to amitriptyline; however, tricyclic antidepressant (TCA)-like wide complex dysrhythmia has not been reported. Our objective was to determine the incidence of TCA-like effects in cyclobenzaprine overdoses as reported to 6 poison centers for 2 years. We compared the incidence of these effects to amitriptyline overdoses collected during the same...
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ژورنال
عنوان ژورنال: Emergency Medicine Journal
سال: 2001
ISSN: 1472-0205,1472-0213
DOI: 10.1136/emj.18.4.236